Thiophene-3-boronic acid → HCID 57799531, compound

HRID 2100945Notes

Reaction equation

HRID 2100945 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[S:21]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22]1>>[CH3:20][C:18]1[NH:17][N:16]=[C:15]([NH:14][C:4]2[N:3]=[C:2]([C:23]3[CH:24]=[CH:25][S:21][CH:22]=3)[C:11]3[C:6]([CH:5]=2)=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=3)[CH:19]=1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 57799548HCID 57799548, compound

Product 1

HCID 57799531HCID 57799531, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and thiophene-3-boronic acid to give (5-methyl-1H-pyrazol-3-yl)-(1-thiophen-3-yl-5-methoxy-isoquinolin-3-yl)-amine. LC-MS m/e 337(MH+).

Sources & evidence

ORD record
ord-1a1dd00f509044da995cd59ed83b6dc2
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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