3-Cyanophenylboronic acid → HCID 23633718, compound

HRID 2100948Notes

Reaction equation

HRID 2100948 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[C:21]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)#[N:22]>>[CH3:20][C:18]1[NH:17][N:16]=[C:15]([NH:14][C:4]2[N:3]=[C:2]([C:27]3[CH:28]=[C:23]([CH:24]=[CH:25][CH:26]=3)[C:21]#[N:22])[C:11]3[C:6]([CH:5]=2)=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=3)[CH:19]=1

Participants

3

Reactant 2

HCID 27343253-Cyanophenylboronic acidHCID 57799548HCID 57799548, compound

Product 1

HCID 23633718HCID 23633718, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and 3-cyano-phenylboronic acid to give 3-[3-(5-methyl-1H-pyrazol-3-ylamino)-5-methoxy-isoquinolin-1-yl]-benzonitrile LC-MS m/e 356(MH+).

Sources & evidence

ORD record
ord-06f25dcd98eb497783ff7378117695a1
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…