Thiophene-3-boronic acid → HCID 57799624, compound

HRID 2100952Notes

Reaction equation

HRID 2100952 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[S:21]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22]1>>[CH3:20][C:18]1[NH:17][N:16]=[C:15]([NH:14][C:4]2[N:3]=[C:2]([C:23]3[CH:24]=[CH:25][S:21][CH:22]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[CH:10]=3)[CH:19]=1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 57799818HCID 57799818, compound

Product 1

HCID 57799624HCID 57799624, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-7-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and thiophene-3-boronic acid to give (5-methyl-1H-pyrazol-3-yl)-(1-thiophen-3-yl-7-methoxy-isoquinolin-3-yl)-amine. LC-MS m/e 337(MH+).

Sources & evidence

ORD record
ord-2618b785983f49e7be9eea692a519772
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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