(3-Ethoxycarbonylphenyl)boronic acid → HCID 178468826, compound

HRID 2100969Notes

Reaction equation

HRID 2100969 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH2:18]([O:20][C:21]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21](=[O:22])[C:23]1[CH:24]=[CH:25][CH:26]=[C:27]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)[CH:28]=1)[CH3:19]

Participants

3

Reactant 2

HCID 3249312(3-Ethoxycarbonylphenyl)boronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178468826HCID 178468826, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-ethoxycarbonyl-phenylboronic acid to give 3-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzoic acid ethyl ester. LC-MS m/e 359(MH+).

Sources & evidence

ORD record
ord-1c72d8b07f2546f1bdc789fd4107890d
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…