4-Ethoxycarbonylphenylboronic acid → HCID 178524251, compound

HRID 2100971Notes

Reaction equation

HRID 2100971 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.C([O:20][C:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)=[O:22])C>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([C:26]3[CH:27]=[CH:28][C:23]([C:21]([OH:22])=[O:20])=[CH:24][CH:25]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 27343504-Ethoxycarbonylphenylboronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178524251HCID 178524251, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-ethoxycarbonyl-phenylboronic acid to give 4-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzoic acid. LC-MS m/e 331(MH+).

Sources & evidence

ORD record
ord-8b388a33e5d74a678169f0fb2b1db5c3
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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