(Naphthalen-2-yl)boronic acid → HCID 178419933, compound

HRID 2100976Notes

Reaction equation

HRID 2100976 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1B(O)O>>[CH:26]1[C:27]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:23]=[CH:24][C:25]=1[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2734375(Naphthalen-2-yl)boronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178419933HCID 178419933, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 2-naphthaleneboronic acid to give (1-naphthalen-2-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 337(MH+).

Sources & evidence

ORD record
ord-62644a5a6385427ca9e0f01973831503
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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