4-tert-Butylphenylboronic acid → HCID 178440779, compound

HRID 2100980Notes

Reaction equation

HRID 2100980 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[C:18]([C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([C:22]1[CH:27]=[CH:26][C:25]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178440779HCID 178440779, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-tert-butylphenylboronic acid to give [1-(4-tert-butyl-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 343(MH+).

Sources & evidence

ORD record
ord-c06154266b1e42d1946552e16db34dce
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…