4-Acetylphenylboronic acid → HCID 178466132, compound

HRID 2100981Notes

Reaction equation

HRID 2100981 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[C:18]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)(=[O:20])[CH3:19]>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([C:24]3[CH:25]=[CH:26][C:21]([C:18](=[O:20])[CH3:19])=[CH:22][CH:23]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 37021224-Acetylphenylboronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178466132HCID 178466132, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-acetyl-phenylboronic acid to give 1-{4-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone. LC-MS m/e 329(MH+).

Sources & evidence

ORD record
ord-c1b0efdb2f6c48459738403bd41ecf6e
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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