4-Methyl-3-thiopheneboronic acid → HCID 178431883, compound

HRID 2100983Notes

Reaction equation

HRID 2100983 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH3:18][C:19]1[C:20](B(O)O)=[CH:21][S:22][CH:23]=1>>[CH3:18][C:19]1[C:20]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)=[CH:21][S:22][CH:23]=1

Participants

3

Reactant 2

HCID 50839314-Methyl-3-thiopheneboronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178431883HCID 178431883, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-methyl-3-thiopheneboronic acid to give [1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 307(MH+).

Sources & evidence

ORD record
ord-82a6890102ca4931882b657415a0d6a7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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