(1-Benzothiophen-3-yl)boronic acid → HCID 178419927, compound

HRID 2100986Notes

Reaction equation

HRID 2100986 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.B(O)(O)[C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[S:21][CH:20]=1>>[S:21]1[CH:20]=[C:19]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]1=2

Participants

3

Reactant 2

HCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178419927HCID 178419927, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and thianaphthene-3-boronic acid to give (1-benzo[b]thiophen-3-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 343(MH+).

Sources & evidence

ORD record
ord-a0aadf6b6def4b94b733906f55b3c716
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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