Thiophene-3-boronic acid → HCID 178419921, compound

HRID 2100987Notes

Reaction equation

HRID 2100987 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[S:18]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19]1>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([C:20]3[CH:21]=[CH:22][S:18][CH:19]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178419921HCID 178419921, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-thiophene boronic acid to give (1H-pyrazol-3-yl)-(1-thiophen-3-yl-isoquinolin-3-yl)-amine. LC-MS m/e 293(MH+).

Sources & evidence

ORD record
ord-9c6b41e7c7f148ccb98f48e54483de6c
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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