4-Cyanophenylboronic acid → HCID 178509636, compound

HRID 2100989Notes

Reaction equation

HRID 2100989 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[C:18]([C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)#[N:19]>>[NH:15]1[CH:16]=[CH:17][C:13]([NH:12][C:4]2[N:3]=[C:2]([C:23]3[CH:24]=[CH:25][C:20]([C:18]#[N:19])=[CH:21][CH:22]=3)[C:11]3[C:6]([CH:5]=2)=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:14]1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 178478391HCID 178478391, compound

Product 1

HCID 178509636HCID 178509636, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-cyano-phenylboronic acid to give 4-[3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile. LC-MS m/e 312(MH+).

Sources & evidence

ORD record
ord-c118e89dae0b43efabde028d10bd1744
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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