3-Acetylphenylboronic acid → HCID 178487347, compound

HRID 2100996Notes

Reaction equation

HRID 2100996 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[C:20]([C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)(=[O:22])[CH3:21]>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([C:27]1[CH:28]=[C:23]([C:20](=[O:22])[CH3:21])[CH:24]=[CH:25][CH:26]=1)=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 27343103-Acetylphenylboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487347HCID 178487347, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-acetyl-phenylboronic acid to give 1-{3-[6-methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone. LC-MS m/e 359(MH+).

Sources & evidence

ORD record
ord-70f03881706e4c13bb252a0526635ca6
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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