3-Cyanophenylboronic acid → HCID 178487349, compound

HRID 2101002Notes

Reaction equation

HRID 2101002 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[C:20]([C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1)#[N:21]>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([C:26]1[CH:27]=[C:22]([CH:23]=[CH:24][CH:25]=1)[C:20]#[N:21])=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 27343253-Cyanophenylboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487349HCID 178487349, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-cyano phenylboronic acid to give 3-[6-methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile. LC-MS m/e 342(MH+).

Sources & evidence

ORD record
ord-bbbc9648905b4792b5265c9e2969d5d7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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