2-Methoxyphenylboronic acid → HCID 178487344, compound

HRID 2101007Notes

Reaction equation

HRID 2101007 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[O:21][CH3:20])=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487344HCID 178487344, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 2-methoxy-phenylboronic acid to give [6-methoxy-1-(2-methoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 347(MH+).

Sources & evidence

ORD record
ord-db55b0aa3c504954bc35998d94d38e6e
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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