3-Tolylboronic acid → HCID 178487345, compound

HRID 2101012Notes

Reaction equation

HRID 2101012 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[C:20]1([CH3:29])[CH:25]=[CH:24][CH:23]=[C:22](B(O)O)[CH:21]=1>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([C:22]1[CH:21]=[C:20]([CH3:29])[CH:25]=[CH:24][CH:23]=1)=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 27339503-Tolylboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487345HCID 178487345, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and m-tolylboronic acid to give (6-methoxy-1-m-tolyl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 331 (MH+).

Sources & evidence

ORD record
ord-1c8a39733d4e47e2b98ad1e5ad4e6cbf
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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