3,4-Dimethoxyphenylboronic acid → HCID 178487365, compound

HRID 2101013Notes

Reaction equation

HRID 2101013 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[CH:18][NH:17][N:16]=3)[N:3]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

3

Reactant 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487365HCID 178487365, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3,4-dimethoxy-phenylboronic acid to give [1-(3,4-dimethoxy-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 377(MH+).

Sources & evidence

ORD record
ord-589e7f61bd6d446e8967a8b676cdf96c
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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