4-Methyl-3-thiopheneboronic acid → HCID 178487379, compound

HRID 2101015Notes

Reaction equation

HRID 2101015 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[CH3:20][C:21]1[C:22](B(O)O)=[CH:23][S:24][CH:25]=1>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([C:22]1[C:21]([CH3:20])=[CH:25][S:24][CH:23]=1)=[N:3][C:4]([NH:14][C:15]1[CH:19]=[CH:18][NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 50839314-Methyl-3-thiopheneboronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487379HCID 178487379, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 4-methyl-3-thiopheneboronic acid to give [6-methoxy-1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine. LC-MS m/e 337(MH+).

Sources & evidence

ORD record
ord-0e282570f77a4e66b01c0f2da147cce2
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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