(1-Benzothiophen-3-yl)boronic acid → HCID 178487378, compound

HRID 2101016Notes

Reaction equation

HRID 2101016 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.B(O)(O)[C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[S:23][CH:22]=1>>[S:23]1[CH:22]=[C:21]([C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[CH:18][NH:17][N:16]=3)[N:3]=2)[C:29]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]1=2

Participants

3

Reactant 2

HCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 178487533HCID 178487533, compound

Product 1

HCID 178487378HCID 178487378, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and thianaphthene-3-boronic acid to give (1-benzo[b]thiophen-3-yl-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine. LC-MS m/e 373(MH+).

Sources & evidence

ORD record
ord-0791be1394a04014a641da6959f53ee5
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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