3,4-Dimethoxyaniline → HCID 178492181, compound

HRID 2101027Notes

Reaction equation

HRID 2101027 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH2:28])[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:28][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 227703,4-DimethoxyanilineHCID 178478391HCID 178478391, compound

Product 1

HCID 178492181HCID 178492181, compound

Procedure

Similar procedure as described in example 273 was used, starting (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3,4-dimethoxy-phenylamine to give N1-(3,4-dimethoxy-phenyl)-N3-(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine. LC-MS m/e 362(MH+).

Sources & evidence

ORD record
ord-114dd94563df402fae124bc62d02bbf7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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