3,5-Dimethoxyaniline → HCID 178493084, compound

HRID 2101028Notes

Reaction equation

HRID 2101028 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:12][C:13]2[CH:17]=[CH:16][NH:15][N:14]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH2:28])[CH:23]=[C:24]([O:26][CH3:27])[CH:25]=1>>[CH3:27][O:26][C:24]1[CH:23]=[C:22]([NH:28][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:12][C:13]3[CH:17]=[CH:16][NH:15][N:14]=3)[N:3]=2)[CH:21]=[C:20]([O:19][CH3:18])[CH:25]=1

Participants

3

Reactant 2

HCID 663013,5-DimethoxyanilineHCID 178478391HCID 178478391, compound

Product 1

HCID 178493084HCID 178493084, compound

Procedure

Similar procedure as described in example 273 was used, starting from (1-chloro-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3,5-dimethoxy-phenylamine to give N1-(3,5-dimethoxy-phenyl)-N3-(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine. LC-MS m/e 362(MH+).

Sources & evidence

ORD record
ord-40b8f096303b4465bd64c82af4bf5855
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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