2-Aminopyridine → HCID 57799762, compound

HRID 2101033Notes

Reaction equation

HRID 2101033 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[NH2:27]>>[CH3:13][O:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([NH:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][N:21]=1)=[N:3][C:4]([NH:14][C:15]1[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 57799762HCID 57799762, compound

Procedure

Similar procedure as described in example 273 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and pyridin-2-ylamine to give 6-Methoxy-N3-(5-methyl-1H-pyrazol-3-yl)-N1-pyridin-2-yl-isoquinoline-1,3-diamine. LC-MS m/e 347(MH+).

Sources & evidence

ORD record
ord-f3c53dbb403e4153aeeb5999b2d6d121
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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