3-Ethylaniline → HCID 178436360, compound

HRID 2101038Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[CH:18][NH:17][N:16]=2)[N:3]=1.[CH2:20]([C:22]1[CH:23]=[C:24]([NH2:28])[CH:25]=[CH:26][CH:27]=1)[CH3:21]>>[CH2:20]([C:22]1[CH:23]=[C:24]([NH:28][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[CH:5]=[C:4]([NH:14][C:15]3[CH:19]=[CH:18][NH:17][N:16]=3)[N:3]=2)[CH:25]=[CH:26][CH:27]=1)[CH3:21]

Participants

Reactant 2

HCID 114753-Ethylaniline

HCID 178487533HCID 178487533, compound

Product 1

HCID 178436360HCID 178436360, compound

Procedure

Similar procedure as described in example 273 was used, starting from (1-chloro-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine and 3-ethyl-phenylamine give N1-(3-ethyl-phenyl)-6-methoxy-N3-(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine. LC-MS m/e 360(MH+).

Sources & evidence

ORD record: ord-8974faa904354be1b55405357566cf17
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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