Hydrogen Bromide → HCID 136055522, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of (6-methoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (100 mg), 40% aq. HBr (1 ml), acetic acid (2 ml) was heated at 180° C. for 30 minutes under microwave irradiation. After reaction finished, the mixture was evaporated to oil by reduced pressure and was dissolved in 50 ml ethyl acetate. The organic layer was washed with aq. NaHCO3 and evaporated to give 70 mg of crude 3-(5-methyl-1H-pyrazol-3-ylamino)-1-phenyl-isoquinolin-6-ol. LC-MS m/e 317(MH+).

Provenance & Evidence