Hydrogen Bromide → HCID 136055516, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of (1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (1 g), 40% aq. HBr (15 ml), acetic acid (50 ml) was heated at 120° C. for 8 hours. After reaction finished, the mixture was evaporated to oil and diluted with 20 ml of ethyl acetate. The organic layer was washed with aq. NaHCO3 and was evaporated to give 450 mg of crude 1-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol by reduced pressure. LC-MS m/e 319(MH+).

Provenance & Evidence