Cyclobutanol → HCID 57799861, compound

HRID 2101062Notes

Reaction equation

HRID 2101062 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:16][C:17]2[CH:21]=[C:20]([CH:22]3[CH2:24][CH2:23]3)[NH:19][N:18]=2)[N:3]=1.[CH:25]1([OH:29])[CH2:28][CH2:27][CH2:26]1>>[CH:25]1([O:29][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[CH:5]=[C:4]([NH:16][C:17]3[CH:21]=[C:20]([CH:22]4[CH2:24][CH2:23]4)[NH:19][N:18]=3)[N:3]=2)[CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 57799781HCID 57799781, compound

Product 1

HCID 57799861HCID 57799861, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-Chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-cyclopropyl-1H-pyrazol-3-yl)-amine and cyclobutanol to give (1-Cyclobutoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-cyclopropyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 381(MH+).

Sources & evidence

ORD record
ord-d186f355c4394e9789e62593ef8da1f7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…