4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane → HCID 57799888, compound

HRID 2101065Notes

Reaction equation

HRID 2101065 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:16][C:17]2[CH:21]=[C:20]([CH:22]3[CH2:24][CH2:23]3)[NH:19][N:18]=2)[N:3]=1.[C:25](B1OC(C)(C)C(C)(C)O1)([CH3:27])=[CH2:26]>>[CH:22]1([C:20]2[NH:19][N:18]=[C:17]([NH:16][C:4]3[N:3]=[C:2]([C:25]([CH3:27])=[CH2:26])[C:11]4[C:6]([CH:5]=3)=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[CH:21]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 109974264,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolaneHCID 57799781HCID 57799781, compound

Product 1

HCID 57799888HCID 57799888, compound

Procedure

Similar procedure as described in example 131 was used, starting from (1-Chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-cyclopropyl-1H-pyrazol-3-yl)-amine and isopropenylboronic acid pinacol ester to give (5-Cyclopropyl-1H-pyrazol-3-yl)-(1-isopropenyl-6,7-dimethoxy-isoquinolin-3-yl)-amine. LC-MS m/e 351(MH+).

Sources & evidence

ORD record
ord-7ad08ce4904447f596551d68cb5773bf
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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