HCID 57799888, compound → HCID 57799639, compound

HRID 2101066Notes

Reaction equation

HRID 2101066 reaction equation
[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH:9][C:10]3[N:11]=[C:12]([C:24]([CH3:26])=[CH2:25])[C:13]4[C:18]([CH:19]=3)=[CH:17][C:16]([O:20][CH3:21])=[C:15]([O:22][CH3:23])[CH:14]=4)[CH:5]=2)[CH2:3][CH2:2]1>[Pd]>[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH:9][C:10]3[N:11]=[C:12]([CH:24]([CH3:26])[CH3:25])[C:13]4[C:18]([CH:19]=3)=[CH:17][C:16]([O:20][CH3:21])=[C:15]([O:22][CH3:23])[CH:14]=4)[CH:5]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 57799888HCID 57799888, compound

Product 1

HCID 57799639HCID 57799639, compoundYield 29.8%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The mixture of (5-Cyclopropyl-1H-pyrazol-3-yl)-(1-isopropenyl-6,7-dimethoxy-isoquinolin-3-yl)-amine (100 mg) and 10% Pd/C (15 mg) was sealed in high-pressure bottle under 40 psi H2 pressure and stirred at room temperature overnight. Then the mixture was filtered, and the filtrate was concentrated to give (5-Cyclopropyl-1H-pyrazol-3-yl)-(1-isopropyl-6,7-dimethoxy-isoquinolin-3-yl)-amine as oil (30 mg). LC-MS: m/e 353 (MH+).

Workup

  1. customwas sealed in high-pressure bottle under 40 psi H2 pressure
  2. filtrationThen the mixture was filtered
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-1c80cbff81fe4d59bfde4641b6e2b3b7
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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