4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane → HCID 136055520, compound

HRID 2101070Notes

Reaction equation

HRID 2101070 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:12])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:13][C:14]2[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=2)[N:3]=1.[C:20](B1OC(C)(C)C(C)(C)O1)([CH3:22])=[CH2:21]>>[C:20]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([OH:12])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:13][C:14]2[CH:18]=[C:17]([CH3:19])[NH:16][N:15]=2)[N:3]=1)([CH3:22])=[CH2:21]

Participants

3

Reactant 2

HCID 109974264,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolaneHCID 136055516HCID 136055516, compound

Product 1

HCID 136055520HCID 136055520, compound

Procedure

Similar procedure as described in example 131 was used, starting from 1-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol and isopropenylboronic acid pinacol ester to give 1-Isopropenyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol. LC-MS m/e 281(MH+).

Sources & evidence

ORD record
ord-bc4bacdeb153490583f2639ffd355780
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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