3-Furanol, tetrahydro- → HCID 57799508, compound

HRID 2101076Notes

Reaction equation

HRID 2101076 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[CH:5]=[C:4]([NH:16][C:17]2[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=2)[N:3]=1.[O:23]1[CH2:27][CH2:26][CH:25]([OH:28])[CH2:24]1>>[CH3:15][O:14][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][C:9]=1[O:12][CH3:13])[C:2]([O:28][CH:25]1[CH2:26][CH2:27][O:23][CH2:24]1)=[N:3][C:4]([NH:16][C:17]1[CH:21]=[C:20]([CH3:22])[NH:19][N:18]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 57799766HCID 57799766, compound

Product 1

HCID 57799508HCID 57799508, compound

Procedure

Similar procedure as described in example 10 was used, starting from (1-Chloro-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and tetrahydro-furan-3-ol to give [6,7-Dimethoxy-1-(tetrahydro-furan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 371(MH+).

Sources & evidence

ORD record
ord-639621c71851430f80cf1fe8aeac1cc1
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…