2-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → HCID 23633712, compound

HRID 2101078Notes

Reaction equation

HRID 2101078 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1.[CH:21](B1OC(C)(C)C(C)(C)O1)=[CH2:22]>>[CH2:21]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[CH:5]=[C:4]([NH:14][C:15]2[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=2)[N:3]=1)[CH3:22]

Participants

3

Reactant 2

HCID 52330122-Ethenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 57799674(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine

Product 1

HCID 23633712HCID 23633712, compound

Procedure

Similar procedure as described in example 330 was used, starting (1-Chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine and ethenylboronic acid pinacol ester to give (1-Ethyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 283(MH+).

Sources & evidence

ORD record
ord-9e00dd7a054d4380bc6b4271133bb3a6
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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