3-Hydroxy-4-methoxybenzenepropanoic acid → 5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

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Reaction Steps

A solution of 3-(3-Hydroxy-4-methoxy-phenyl)-propionic acid in methanesulfonic acid (10 ml) was heated at 90° C. for 10 minutes under microwave irradiation. The mixture was poured into ice (300 g) and stirred for 1 hour. The precipitate was collected and dried to give 5-Hydroxy-6-methoxy-indan-1-one (2 g). LC-MS: m/e 179 (MH+).

Provenance & Evidence