1H-Pyrazol-3-amine, 5-methyl- → HCID 57799711, compound

HRID 2101084Notes

Reaction equation

HRID 2101084 reaction equation
[CH2:1]([O:8][C:9]1[C:17]([O:18][CH3:19])=[CH:16][C:12]([C:13](O)=[O:14])=[C:11]([CH2:20][C:21]#[N:22])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:23][C:24]1[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:12](=[CH:16][C:17]=1[O:18][CH3:19])[C:13](=[O:14])[NH:22][C:21]([NH:23][C:24]1[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=1)=[CH:20]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 57799742HCID 57799742, compound

Product 1

HCID 57799711HCID 57799711, compound

Procedure

Similar procedure as described in example 2c was used, starting from 4-Benzyloxy-2-cyanomethyl-5-methoxy-benzoic acid and 3-amino-5-methyl-1H-pyrazole to give 6-Benzyloxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-2H-isoquinolin-1-one. LC-MS: m/e 377 (MH+).

Sources & evidence

ORD record
ord-c3a2fcde4f7b4fd5b18ac31cfb5c3249
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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