4-(2-Chloroethyl)morpholine → HCID 57799878, compound

HRID 2101088Notes

Reaction equation

HRID 2101088 reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].Cl[CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 767274-(2-Chloroethyl)morpholineHCID 136055517HCID 136055517, compound

Product 1

HCID 57799878HCID 57799878, compound

Procedure

Similar procedure as described in example 329 was used, starting from 1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol and N-(2-chloroethyl)-morpholine to give [1-Isopropoxy-7-methoxy-6-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 442(MH+).

Sources & evidence

ORD record
ord-cd875c4c6f1a4763ba2bb809c5f5972a
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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