2H-Pyran, 4-chlorotetrahydro- → HCID 57799564, compound

HRID 2101089Notes

Reaction equation

HRID 2101089 reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([OH:17])=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].Cl[CH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:12]([O:15][CH3:16])[CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 1372022H-Pyran, 4-chlorotetrahydro-HCID 136055517HCID 136055517, compound

Product 1

HCID 57799564HCID 57799564, compound

Procedure

Similar procedure as described in example 328 was used, starting from 1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ol and 4-chloro-tetrahydropyran to give [1-Isopropoxy-7-methoxy-6-(tetrahydro-pyran-4-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS m/e 413(MH+).

Sources & evidence

ORD record
ord-f19481d095024f8d87ff168bc045d487
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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