1H-Pyrazol-3-amine, 5-methyl- → HCID 57799636, compound

HRID 2101097Notes

Reaction equation

HRID 2101097 reaction equation
[C:1]([CH2:3][C:4]1[CH:12]=[C:11]([F:13])[C:10]([O:14][CH2:15][CH2:16][O:17][CH3:18])=[CH:9][C:5]=1[C:6](O)=[O:7])#[N:2].[NH2:19][C:20]1[CH:24]=[C:23]([CH3:25])[NH:22][N:21]=1>>[F:13][C:11]1[CH:12]=[C:4]2[C:5](=[CH:9][C:10]=1[O:14][CH2:15][CH2:16][O:17][CH3:18])[C:6](=[O:7])[NH:2][C:1]([NH:19][C:20]1[CH:24]=[C:23]([CH3:25])[NH:22][N:21]=1)=[CH:3]2

Participants

3

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 57799512HCID 57799512, compound

Product 1

HCID 57799636HCID 57799636, compound

Procedure

Similar procedure as described in example 2c was used, starting from 2-Cyanomethyl-4-fluoro-5-(2-methoxy-ethoxy)-benzoic acid and 3-amino-5-methylpyrazole to give 6-Fluoro-7-(2-methoxy-ethoxy)-3-(5-methyl-1H-pyrazol-3-ylamino)-2H-isoquinolin-1-one. LC-MS: m/e 333 (MH+).

Sources & evidence

ORD record
ord-e37035f88389480d8ef4c8a0de617d84
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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