Tetrahydrofuran → HCID 57799756, compound

Participants

Reaction Conditions

Reaction Steps

A 2.0˜5.0 mL process vial was charged with trifluoro-methanesulfonic acid 1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (56.2 mg, 1 mmol), Pd(OAc)2 (4 mg), Mo(CO)6 (26.4 mg), morpholine (26.0 mg), DBU (45 mg), and dry THF (2 mL). The vial was immediately capped under air and heated at 150° C. for 15 min under microwave irradiation. After cooling, the reaction mixture was filtered through a short silica gel column, and the solvent was removed under reduced pressure. The residue was sent to prep-HPLC to give 5 mg of [1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-morpholin-4-yl-methanone as a yellow solid. LC-MS m/e 396 (MH+).

Provenance & Evidence