Morpholine → HCID 23633645, compound

HRID 2101109Notes

Reaction equation

[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10](OS(C(F)(F)F)(=O)=O)=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:5]=1)([CH3:3])[CH3:2].[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[CH:1]([C:4]1[C:13]2[C:8](=[CH:9][C:10]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[CH:11][CH:12]=2)[CH:7]=[C:6]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 8083Morpholine

HCID 86613880HCID 86613880, compound

Product 1

HCID 23633645HCID 23633645, compound

Procedure

Similar procedure as described in the example 363 was used, starting from Trifluoro-methanesulfonic acid 1-isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester and morpholine to give 5 mg of (1-Isopropyl-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine as a yellow solid. LC-MS m/e 352 (MH+).

Sources & evidence

ORD record: ord-7324f8ce1a524e9da0b4f7850879bf9e
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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