Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | HCID 57799673 | HCID 57799673 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57799574 | HCID 57799574 | — |
Reaction Steps
Under Ar, trifluoro-methanesulfonic acid 7-fluoro-1-isopropoxy-3-(5-methyl-1-trifluoromethanesulfonyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl ester (60 mg), pyrrolidin-2-one, Pd2 (dba)3 (4.8 mg), Xantphos (12 mg) and K3PO4 (61.8 mg) were added to dioxane (5 ml), the mixture was heated at 100° C. for 20 hrs. The mixture was filtrated, and the filtrate was concentrated to give crude product. It was purified by preparative LC-MS to give 1-[7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-pyrrolidin-2-one (20 mg). LC-MS: m/e 384 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07572809B2 |
|---|
| Source dataset | uspto-grants-2009_08 |
|---|
| ORD ID | ord-0b714f2aa99542dc8be4edd24384eab0 |
|---|
| Source note | uspto-grants-2009_08 |
|---|
