2-Chloro-3,4-dimethoxycinnamic acid → 3-(2-Chloro-3,4-dimethoxyphenyl)propanoic acid

HRID 2101134Notes

Reaction equation

HRID 2101134 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[CH:12]=[CH:13][C:14]([OH:16])=[O:15]>[Pd]>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([O:10][CH3:11])[CH:5]=[CH:4][C:3]=1[CH2:12][CH2:13][C:14]([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 27749672-Chloro-3,4-dimethoxycinnamic acid

Product 1

HCID 577997953-(2-Chloro-3,4-dimethoxyphenyl)propanoic acid

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Similar procedure as described in example 9B was used, starting from 3-(2-Chloro-3,4-dimethoxy-phenyl)-acrylic acid and Pd—C to give 3-(2-Chloro-3,4-dimethoxy-phenyl)-propionic acid. LC-MS: m/e 243 (M−1).

Sources & evidence

ORD record
ord-8fe55b0e6c9a46d6a3cb2cb2c6b4360c
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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