1H-Pyrazol-3-amine, 5-methyl- → HCID 178428170, compound

HRID 2101143Notes

Reaction equation

HRID 2101143 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH2:11][C:12]#[N:13])[CH:3]=1.[NH2:14][C:15]1[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=1>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6]([OH:7])=[N:13][C:12]([NH:14][C:15]1[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=1)=[CH:11]2

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 577994854-Bromo-2-(cyanomethyl)benzoic acid

Product 1

HCID 178428170HCID 178428170, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 9B was used, starting from 4-Bromo-2-cyanomethyl-benzoic acid, 3-amino-5-methylpyrazole and acetic acid to give 6-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol. LC-MS: m/e 319 (MH+).

Sources & evidence

ORD record
ord-3ceb26c6dc08443e9c2ad224230f93bd
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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