反应详情

Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid isopropyl ester (300 mg) was dissolved in KOH and MeOH (1:1, 10 ml), the mixture was stirred at room temperature for 20 hrs, the MeOH was evaporated and neutralized with concentrated HCl (PH=3). The solid was collected to give 240 mg of desired product (91% yield). LC-MS: m/e 325 (M−1).

1. customthe MeOH was evaporated
2. customThe solid was collected