Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid isopropyl ester → 1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid

HRID 2101146Notes

Reaction equation

HRID 2101146 reaction equation
C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([O:17][CH:18]([CH3:20])[CH3:19])=[N:12][C:11]([NH:21][C:22]1[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=1)=[CH:10]2)=[O:6])(C)C>[OH-].[K+].CO>[CH:18]([O:17][C:13]1[C:14]2[C:9](=[CH:8][C:7]([C:5]([OH:6])=[O:4])=[CH:16][CH:15]=2)[CH:10]=[C:11]([NH:21][C:22]2[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=2)[N:12]=1)([CH3:20])[CH3:19]

Participants

4

Reactant 1

HCID 57799547Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid isopropyl ester

Product 1

HCID 577994701-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acidYield 91%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14797Potassium HydroxideSolvent

Procedure

Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid isopropyl ester (300 mg) was dissolved in KOH and MeOH (1:1, 10 ml), the mixture was stirred at room temperature for 20 hrs, the MeOH was evaporated and neutralized with concentrated HCl (PH=3). The solid was collected to give 240 mg of desired product (91% yield). LC-MS: m/e 325 (M−1).

Workup

  1. customthe MeOH was evaporated
  2. customThe solid was collected

Sources & evidence

ORD record
ord-81ed29f67cb24cd2b621d28485ae06dd
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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