1-Acetylpiperazine → HCID 57799507, compound
Reaction equation
[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([OH:17])=O)=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2].[C:25]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)(=[O:27])[CH3:26]>>[CH:1]([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([C:15]([N:31]3[CH2:32][CH2:33][N:28]([C:25](=[O:27])[CH3:26])[CH2:29][CH2:30]3)=[O:17])=[CH:12][CH:13]=2)[CH:8]=[C:7]([NH:18][C:19]2[CH:23]=[C:22]([CH3:24])[NH:21][N:20]=2)[N:6]=1)([CH3:3])[CH3:2]Participants
3
Procedure
Similar procedure as described in example 384 was used, starting from 1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid and 1-acetylpiperazine to give 1-{4-[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carbonyl]-piperazin-1-yl}-ethanone. LC-MS: m/e 437 (MH+).
Sources & evidence
- ORD record
- ord-3b91bf39f10c4a5188acd44220ded0e2
- Source dataset
- uspto-grants-2009_08
- Patent number
- US07572809B2
Reaction notes
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