1H-Pyrazol-3-amine, 5-methyl- → HCID 178428171, compound

HRID 2101168Notes

Reaction equation

HRID 2101168 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:11][C:12]#[N:13])=[C:6]([CH:10]=1)[C:7](O)=[O:8].[NH2:14][C:15]1[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=1>C(O)(=O)C>[Br:1][C:2]1[CH:10]=[C:6]2[C:5]([CH:11]=[C:12]([NH:14][C:15]3[CH:19]=[C:18]([CH3:20])[NH:17][N:16]=3)[N:13]=[C:7]2[OH:8])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 577997485-Bromo-2-(cyanomethyl)benzoic acid

Product 1

HCID 178428171HCID 178428171, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Similar procedure as described in example 9B was used, starting from 5-Bromo-2-cyanomethyl-benzoic acid, 3-amino-5-methylpyrazol and acetic acid to give 7-Bromo-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ol. LC-MS: m/e 319 (MH+).

Sources & evidence

ORD record
ord-705df885fb714c9e8b32f73c5f79b2d9
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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