Cyclobutanol → HCID 57799491, compound

HRID 2101171Notes

Reaction equation

HRID 2101171 reaction equation
[CH:1]1([OH:5])[CH2:4][CH2:3][CH2:2]1.Cl[C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:22][CH3:23])=[C:14]([O:17][CH2:18][CH2:19][O:20][CH3:21])[CH:15]=2)[CH:10]=[C:9]([NH:24][C:25]2[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=2)[N:8]=1>>[CH:1]1([O:5][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:22][CH3:23])=[C:14]([O:17][CH2:18][CH2:19][O:20][CH3:21])[CH:15]=3)[CH:10]=[C:9]([NH:24][C:25]3[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=3)[N:8]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 76218CyclobutanolHCID 57799568HCID 57799568, compound

Product 1

HCID 57799491HCID 57799491, compound

Procedure

Similar procedure as described in example 400 was used, starting from cyclobutanol and [1-Chloro-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine to give [1-Cyclobutoxy-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 399(MH+).

Sources & evidence

ORD record
ord-c61388207a1640dd85ddc951c7992d9f
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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