3-Furanol, tetrahydro- → HCID 57799588, compound

HRID 2101172Notes

Reaction equation

HRID 2101172 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1.Cl[C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:23][CH3:24])=[C:15]([O:18][CH2:19][CH2:20][O:21][CH3:22])[CH:16]=2)[CH:11]=[C:10]([NH:25][C:26]2[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=2)[N:9]=1>>[CH3:24][O:23][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][C:15]=1[O:18][CH2:19][CH2:20][O:21][CH3:22])[C:8]([O:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1)=[N:9][C:10]([NH:25][C:26]1[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=1)=[CH:11]2

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 57799568HCID 57799568, compound

Product 1

HCID 57799588HCID 57799588, compound

Procedure

Similar procedure as described in example 400 was used, starting from 3-hydroxy-tetrahydrofuran and [1-Chloro-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine to give [6-Methoxy-7-(2-methoxy-ethoxy)-1-(tetrahydro-furan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 415(MH+).

Sources & evidence

ORD record
ord-4e286cea6fbe40128527c2da15aee573
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

Loading…