Oxetan-3-ol → HCID 57799573, compound

HRID 2101173Notes

Reaction equation

HRID 2101173 reaction equation
[O:1]1[CH2:4][CH:3]([OH:5])[CH2:2]1.Cl[C:7]1[C:16]2[C:11](=[CH:12][C:13]([O:22][CH3:23])=[C:14]([O:17][CH2:18][CH2:19][O:20][CH3:21])[CH:15]=2)[CH:10]=[C:9]([NH:24][C:25]2[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=2)[N:8]=1>>[CH3:23][O:22][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][C:14]=1[O:17][CH2:18][CH2:19][O:20][CH3:21])[C:7]([O:5][CH:3]1[CH2:4][O:1][CH2:2]1)=[N:8][C:9]([NH:24][C:25]1[CH:29]=[C:28]([CH3:30])[NH:27][N:26]=1)=[CH:10]2

Participants

3

Reactant 2

HCID 9942117Oxetan-3-olHCID 57799568HCID 57799568, compound

Product 1

HCID 57799573HCID 57799573, compound

Procedure

Similar procedure as described in example 400 was used, starting from oxetan-3-ol and [1-Chloro-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine to give [6-Methoxy-7-(2-methoxy-ethoxy)-1-(oxetan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine. LC-MS: m/e 401 (MH+).

Sources & evidence

ORD record
ord-f6eab694a6994ba698ba3d78b5637b4c
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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