Cyclobutanol → HCID 57799578, compound

HRID 2101180Notes

Reaction equation

[CH:1]1([OH:5])[CH2:4][CH2:3][CH2:2]1.[CH3:6][N:7]([CH3:30])[C:8]([C:10]1[CH:19]=[C:18]2[C:13]([CH:14]=[C:15]([NH:21][C:22]3[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=3)[N:16]=[C:17]2Cl)=[CH:12][C:11]=1[O:28][CH3:29])=[O:9]>>[CH3:30][N:7]([CH3:6])[C:8]([C:10]1[CH:19]=[C:18]2[C:13]([CH:14]=[C:15]([NH:21][C:22]3[CH:26]=[C:25]([CH3:27])[NH:24][N:23]=3)[N:16]=[C:17]2[O:5][CH:1]2[CH2:4][CH2:3][CH2:2]2)=[CH:12][C:11]=1[O:28][CH3:29])=[O:9]

Participants

Reactant 2

HCID 76218Cyclobutanol

HCID 57799501HCID 57799501, compound

Product 1

HCID 57799578HCID 57799578, compound

Procedure

Similar procedure as described in example 400 was used, starting from cyclobutanol and 1-Chloro-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carboxylic acid dimethylamide to give 1-Cyclobutoxy-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carboxylic acid dimethylamide, LC-MS: m/e 396(MH+).

Sources & evidence

ORD record: ord-0d5850a249b743f9bd331996bdc40b0a
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07572809B2

Reaction notes

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