3-Furanol, tetrahydro- → HCID 68972439, compound

HRID 2101183Notes

Reaction equation

HRID 2101183 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1.Cl[C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([C:18]#[N:19])[CH:16]=2)[CH:11]=[C:10]([NH:22][C:23]2[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=2)[N:9]=1>>[CH3:21][O:20][C:14]1[CH:13]=[C:12]2[C:17](=[CH:16][C:15]=1[C:18]#[N:19])[C:8]([O:1][CH:2]1[CH2:6][CH2:5][O:4][CH2:3]1)=[N:9][C:10]([NH:22][C:23]1[CH:27]=[C:26]([CH3:28])[NH:25][N:24]=1)=[CH:11]2

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 57799589HCID 57799589, compound

Product 1

HCID 68972439HCID 68972439, compound

Procedure

Similar procedure as described in example 400 was used, starting from 3-hydroxy-tetrahydrofuran and of 1-Chloro-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carbonitrile to give 6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-1-(tetrahydro-furan-3-yloxy)-isoquinoline-7-carbonitrile. LC-MS: m/e 366(MH+).

Sources & evidence

ORD record
ord-4c594939a5f042ad91f10732eab4d8fc
Source dataset
uspto-grants-2009_08
Patent number
US07572809B2

Reaction notes

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