Potassium Phosphate, Tribasic → HCID 57799797, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	Tris(1,1-dimethylethyl)phosphine	HCID 83681	—
Reactant	Cyclopropylboronic acid	HCID 2760897	—
Reactant	(1-chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine	HCID 57799674	—
Catalyst	Palladium Chloride	HCID 24290	—
Solvent	1,4-Dioxane--water (1/1)	HCID 21886435	—
Product	HCID 57799797	HCID 57799797	0.8%

Reaction Conditions

Temperature	130 °C

Reaction Steps

To a mixture of (1-Chloro-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine (0.2887 g 1 mmol), cyclopropyl boronic acid (0.1718 g, 2 mmol), PdCl2 (0.0177 g, 10% mmol), and K3PO4 (0.5307 g, 2.5 mmol) under Argon was added Dioxane/H2O=10:1(1 ml) and P(tBu)3 (20% mmol). The mixture was heated to 130° C. and stirred overnight. The product was purified by preparative HPLC to give 2.5 mg of solid. LC-MS: m/e 295 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07572809B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-c0b83d7aca5b4d6294df95c8b3aa03e9
Source note	uspto-grants-2009_08